#STATINS AND GRAPEFRUIT WARNINGS PROFESSIONAL#

Use this medicine only as directed by your doctor. Liver enzymes, elevated-Should not be used in patients with these conditions. Sepsis (severe infection)-Patients with these conditions may be at risk for muscle or kidney problems.ĭiabetes-Use with caution. Metabolic enzyme deficiency or disorder, severe or Hypothyroidism (underactive thyroid), inadequately treated or May cause side effects to become worse.Īsian descent-May need a lower dose of this medicine.Įlectrolyte deficiency or disorder, severe or Liver disease, history of-Use with caution.

Make sure you tell your doctor if you have any other medical problems, especially: The presence of other medical problems may affect the use of this medicine.

#STATINS AND GRAPEFRUIT WARNINGS PROFESSIONAL#

Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Using alcohol or tobacco with certain medicines may also cause interactions to occur. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.Ĭertain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Drug InteractionsĪlthough certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding.

However, elderly patients are more likely to have age-related muscle problems, which may require caution in patients receiving rosuvastatin. GeriatricĪppropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rosuvastatin in the elderly. Safety and efficacy have not been established. However, safety and efficacy have not been established in children younger than 7 years of age.Īppropriate studies have not been performed on the relationship of age to the effects of rosuvastatin capsule in the pediatric population. You may see printed warnings and precautions based on these kinds of studies, but the warnings do not apply to typical or customary amounts of grapefruit of GFJ.Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of rosuvastatin tablet in children 7 years of age and older. An important point is that some of the research studies involving GFJ and statins used unrealistically large quantities of GFJ, or ‘super-strength’ forms of GFJ. These include: atorvastatin (Lipitor), lovastatin (Mevacor), fluvastatin (Lescol), pitavastatin (Livalo), pravastatin (Pravachol), and rosuvastatin (Crestor). All other statin derivatives are not meaningfully affected by typical quantities of grapefruit or GFJ. The GFJ-simvastatin combination is best avoided, and another statin used in its place. The only statin medication that is meaningfully affected by an interaction with customary amounts of grapefruit juice (GFJ) is simvastatin. The result is that medications ordinarily metabolized by intestinal CYP3A may end up with greater absorption and higher levels in blood, as if a higher dose were taken. The grapefruit itself, and juice made from the fruit, contain natural substances called furanocoumarins, which have the effect of inactivating CYP3A in the intestinal wall. Greenblatt, MD, answers: “With the exception of simvastatin (Zocor), it is safe to take statin medications with customary amounts of grapefruit products – such as one glass of typical commercially-available grapefruit juice, or one-half of a whole grapefruit.Ī number of medications, including some statins, are metabolized (broken down) by an enzyme in the wall of the intestines, termed Cytochrome P450-3A, often abbreviated CYP3A.

Statins and grapefruit warnings